Comparison of the effect of neostigmine and sugammadex on postoperative delirium in surgical patients: A systematic review and meta-analysis.

Key Points

• This review aims to compare the impact of sugammadex and neostigmine on postoperative delirium in surgical patients.
• Conducted a systematic review and meta-analysis
• Included randomized controlled trials (RCTs) and non-randomized controlled trials (NRCTs)
• Analyzed postoperative delirium incidence within 24 hours after surgery
• Sugammadex is linked to a lower incidence of postoperative delirium compared to neostigmine
• The significant effect was primarily seen in RCTs, not in NRCTs