What does this research mean for the field?

Salivary cortisol (CORT) is a practical biomarker for non-invasive monitoring of stress in first responders, while salivary C-reactive protein (CRP) and interleukin-6 (IL-6) require further validation as substitutes for blood biomarkers. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The research aims to validate non-invasive assessments of physiological stress and inflammation among first responders.

March 12, 2026Journal of Occupational and Environmental Medicine0 citations

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Validation of A Non-Invasive Physiological Stress and Inflammatory Assessment: Agreement of Salivary and Blood Biomarkers Among First Responders

DGDrew E. Gonzalez SMS. Martin MMMatthew J. McAllister

Key Points

The research aims to validate non-invasive assessments of physiological stress and inflammation among first responders.
Compared salivary and blood biomarkers of stress and inflammation among first responders.
Focused on salivary cortisol, CRP, and IL-6 levels.
Evaluated the practicality of using salivary samples in operational settings.
Salivary cortisol showed practicality for non-invasive monitoring.
Caution is advised regarding the use of salivary CRP and IL-6 as substitutes for blood measures.
Further research is necessary to confirm the reliability of salivary CRP and IL-6.

Abstract

Overall, while salivary CORT is practical for non-invasive monitoring in operational settings, caution is warranted with salivary CRP and IL-6, which need further research as blood substitutes.

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Validation of A Non-Invasive Physiological Stress and Inflammatory Assessment: Agreement of Salivary and Blood Biomarkers Among First Responders

Key Points

Abstract

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