Phenolic reaction products of nitrogen mustards and N,N-dialkylaminoethyl-2-chlorides were comprehensively characterised, including isomer differentiation, through their ESI-MS/MS product ion spectra. The validated LC-MS/MS neutral-loss scan method enabled efficient screening of these markers in complex samples. These LC-MS/MS methods are highly valuable for OPCW proficiency testing and CWC verification programs.
Singh et al. (Tue,) studied this question.