What type of study is this?

This is a In Vitro Study study.

What question did this study set out to answer?

To evaluate the performance of the AeroVent Plus holding chamber for delivering bronchodilators during mechanical ventilation.

March 14, 2026

In vitro performance of an improved collapsible holding chamber (CHC) for the delivery of bronchodilators to patients receiving mechanical ventilation

Key Points

To evaluate the performance of the AeroVent Plus holding chamber for delivering bronchodilators during mechanical ventilation.
Evaluated AeroVent Plus and Spirale CHC under simulated mechanical ventilation conditions.
Used an adult test lung to mimic patient conditions.
Measured aerosol delivery after 6 respiratory cycles using HPLC-UV spectrophotometry.
AeroVent Plus delivered a total mass of 22.7±3.1 μg/actuation of salbutamol.
Spirale CHC delivered a total mass of 4.7±0.7 μg/actuation of salbutamol.
Significant difference in drug output between AeroVent Plus and Spirale CHCs.

Abstract

Bronchodilator delivery by pressurized metered-dose inhaler (pMDI) to patients on mechanical ventilation is best achieved without breaking the breathing circuit. We describe an evaluation of an improved CHC (AeroVent Plus*, Trudell Medical International, London, Canada (n=5 devices, 1 measurement/device)), in which the pMDI canister receptacle is offset from the CHC axis to reduce internal impaction, and can also accept GSK pMDI canisters having a dose counter. Delivery of 3-actuations of salbutamol (HFA-Ventolin*, GSK (Canada); 100-μg/actuation) was assessed with the expanded CHC inserted in the inspiratory limb of an adult breathing circuit equipped with a 7-mm diameter endotracheal tube (ETT). An adult test lung (Michigan Instruments) was used to simulate the patient. The circuit was humidified near to body conditions (T = 36°C, 100%RH), and tidal breathing (600-mL, duty cycle = 33%, 10 breaths/min) was simulated by a servo ventilator (Siemens, model 900C). A filter was located between the distal end of the ETT and test lung to collect the aerosol. Total mass (TM) of salbutamol after 6 respiratory cycles was determined by HPLC-UV spectrophotometry. Similar measurements were undertaken with a Spirale* CHC (Armstrong Medical), providing benchmark data from a European marketed CHC having the pMDI receptacle in-line with the axis of the device. TM (mean ± S.D.) from the AeroVent Plus and Spirale CHCs was 22.7±3.1 and 4.7±0.7 μg/actuation respectively. Clinicians using these devices should be aware of the implications of the difference in drug output between these apparently similar devices.

问 AI

Bookmark