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Investigate the role of calcitriol in ionized hypercalcemia among dogs with chronic dermatopathy.

March 14, 2026Journal of Veterinary Internal Medicine0 citationsOpen Access

Endogenous calcitriol production and ionized hypercalcemia in 7 dogs with chronic dermatopathy of infectious and noninfectious etiology (2016-2024)

JBJean M. BrudvigMichigan State University DLDaniel K. LangloisMichigan State University JJJared A. JaffeyMidwestern University

Key Points

Investigate the role of calcitriol in ionized hypercalcemia among dogs with chronic dermatopathy.
Case analysis of 7 dogs diagnosed with chronic dermatopathy
Assessment of ionized hypercalcemia and calcitriol levels
Comparative analysis of infectious and noninfectious etiologies
Ionized hypercalcemia was identified in all dogs studied
Excessive extrarenal calcitriol production correlated with skin disease
Calcitriol measurement proved crucial for diagnosing unexplained hypercalcemia in this context

Abstract

Ionized hypercalcemia apparently mediated by excessive extrarenal calcitriol production can be seen in dogs with granulomatous skin disease. Calcitriol measurement should be included with other calcium-related testing in the workup of unexplained hypercalcemia with concurrent chronic skin disease.

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