March 15, 2026Open Access

The Association of Iatrogenic Withdrawal With Opioid and Benzodiazepine Weaning in Children With Bronchiolitis: A Single-Center, Retrospective Cohort Study, 2012–2022

Key Points

To investigate the association of iatrogenic withdrawal with opioid and benzodiazepine weaning in children with bronchiolitis.
Single-center, retrospective cohort study from 2012 to 2022
Analysis of cumulative IV opioid dose and weaning protocols
Assessment of withdrawal risk based on CCC-V2 categories
Higher cumulative IV opioid doses linked to increased withdrawal odds
Recent IV opioid weaning within 8-12 hours correlated with withdrawal
Morphine usage associated with significantly higher odds of withdrawal

Abstract

Patients with a higher cumulative IV opioid dose, an IV opioid wean in the preceding 8-12 hours, and greater than or equal to 2 CCC-V2 categories had the highest odds of withdrawal in this single-center study. Morphine was associated with increased odds of withdrawal as well.

The Association of Iatrogenic Withdrawal With Opioid and Benzodiazepine Weaning in Children With Bronchiolitis: A Single-Center, Retrospective Cohort Study, 2012–2022

Key Points

Abstract

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