What question did this study set out to answer?

To investigate the genetic mutations in efflux pump genes of Salmonella typhi and their role in antibiotic resistance.

March 17, 2026Current Pharmaceutical Design0 citations

Molecular Insights into the MdtABC Efflux Pump Genes in Clinical Salmonella typhi Isolates from Typhoid Patients

M.Muhammad .University of Peshawar SASadiq AzamThe University of Agriculture, Peshawar NRNoor RehmanBacha Khan University

Key Points

To investigate the genetic mutations in efflux pump genes of Salmonella typhi and their role in antibiotic resistance.
Analyzed clinical isolates of Salmonella typhi from typhoid patients.
Examined mutations in mdtABC efflux pump genes.
Evaluated the relationship between mutations and antibiotic resistance.
Observed a significant increase in multidrug resistance among the isolates.
Identified key mutations that likely enhance efflux pump function.
Correlated specific genetic variations with levels of antibiotic resistance.

Abstract

This study highlights the alarming rise of multidrug resistance in S. typhi isolates and identifies key genetic mutations that may influence efflux pump function, potentially contributing to enhanced antibiotic resistance.

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