March 18, 2026Food & Function0 citationsOpen Access
Ketogenic diet derived faecal microbiota transplantation improved sensorimotor gating deficit in an acute NMDA-receptor antagonist model of schizophrenia in mice
To investigate the effects of a ketogenic diet-derived faecal microbiota transplantation on sensorimotor gating deficits in a mouse model of schizophrenia.
Utilized an acute NMDA-receptor antagonist model to induce schizophrenia-like symptoms in mice.
Administered ketogenic diet and performed faecal microbiota transplantation.
Assessed sensorimotor gating using pre-pulse inhibition tests.
Mice receiving the ketogenic diet and transplant showed improved sensorimotor gating.
Demonstrated a significant reduction in deficits compared to control groups.
Abstract
Ketogenic diet (KD) shows promise as a novel treatment for schizophrenia, although its mechanisms of action are still unclear. KD has been shown to modify the gut microbiota and may...
Ketogenic diet derived faecal microbiota transplantation improved sensorimotor gating deficit in an acute NMDA-receptor antagonist model of schizophrenia in mice | Synapse