B-cell monitoring predicts infection risk in childhood systemic lupus erythematosus patients on belimumab | Synapse
March 18, 2026
B-cell monitoring predicts infection risk in childhood systemic lupus erythematosus patients on belimumab
Key Points
The research aims to identify predictors of infection risk in childhood systemic lupus erythematosus patients undergoing treatment with belimumab.
Analyzed the effects of belimumab on B cell depletion and immunoglobulin G levels.
Developed a nomogram for risk stratification based on early B cell and IgG changes.
Profound B cell depletion is associated with a higher infection risk.
Significant reduction in IgG levels correlates with increased susceptibility to infections.
The nomogram serves as a practical tool for monitoring and risk assessment.
Abstract
Early, profound B cell depletion and IgG reduction are key predictors of infection in belimumab-treated cSLE. Our nomogram provides a practical tool for risk stratification and personalized monitoring.