METTL3 stabilizes FASN mRNA by mediating m6A modification to promote malignant progression of diffuse large B-cell lymphoma

Key Points

• The study investigates how METTL3 influences FASN mRNA stability and its impact on DLBCL progression.
• Analyzed METTL3's role in FASN mRNA stabilization
• Assessed signaling pathways involved in DLBCL progression
• Examined ER stress response mechanisms
• METTL3 significantly enhances FASN expression through m6A modification
• Activation of PI3K/AKT and MAPK/ERK pathways was observed
• ER stress response was inhibited in METTL3/FASN-high DLBCL