What question did this study set out to answer?

This research aims to identify hidden changes in glucose metabolism among patients on the transplant waitlist.

March 23, 2026Nefrología (English Edition)0 citationsOpen Access

Masked alterations of glucose metabolism among patients awaiting kidney transplantation: Metabolic phenotyping and screening strategies

ETElena Terán-GarcíaHospital Universitario de Canarias LPLourdes Perez-TamajónHospital Universitario de Canarias CRClaudia Rodríguez-LópezCentro de Biología Molecular Severo Ochoa

Key Points

This research aims to identify hidden changes in glucose metabolism among patients on the transplant waitlist.
Analyzed glucose metabolism using oral glucose tolerance tests (OGTT)
Assessed risk factors like age, fasting glucose, and statin use
Evaluated the need for routine testing based on specific thresholds
One-third of patients awaiting transplants show abnormal OGTT results despite no diabetes symptoms
Younger patients without high fasting glucose and statin use have lower abnormal OGTT likelihood
Annual OGTT testing may be recommended for overweight/obese patients who initially test normal

Abstract

One-third of wait-listed patients without manifest diabetes exhibit abnormal OGTT. Age, fasting glucose, and statin use increase risk. Patients below age and fasting glucose thresholds, without statins, have low abnormal OGTT likelihood, potentially reducing routine testing. Annual OGTT may benefit patients initially with normal results, if overweight/obese, or on statins.

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