To assess the population-level impact of doxycycline post-exposure prophylaxis on syphilis diagnoses.
Conducted an interrupted time series analysis of syphilis cases before and after doxycycline prophylaxis implementation.
Analyzed syphilis diagnosis trends among various demographic groups, including cisgender women and pregnant persons.
Syphilis diagnoses among cisgender women declined significantly after doxycycline prophylaxis implementation.
Pregnant persons and congenital syphilis cases did not show a decline, indicating a gap in effectiveness.
Abstract
After the implementation of doxy-PEP, syphilis diagnoses declined dramatically, including among cisgender women. This decline has not affected syphilis in pregnant persons or CS.