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March 28, 2026Clinical Infectious Diseases3 citations

The population-level impact of doxycycline post-exposure prophylaxis on syphilis in King County, WA: an interrupted time series analysis

TMTimothy W Menza ABAnna BerzkalnsPublic Health – Seattle & King County CCChase CannonPublic Health – Seattle & King County

Puntos clave

To assess the population-level impact of doxycycline post-exposure prophylaxis on syphilis diagnoses.
Conducted an interrupted time series analysis of syphilis cases before and after doxycycline prophylaxis implementation.
Analyzed syphilis diagnosis trends among various demographic groups, including cisgender women and pregnant persons.
Syphilis diagnoses among cisgender women declined significantly after doxycycline prophylaxis implementation.
Pregnant persons and congenital syphilis cases did not show a decline, indicating a gap in effectiveness.

Resumen

After the implementation of doxy-PEP, syphilis diagnoses declined dramatically, including among cisgender women. This decline has not affected syphilis in pregnant persons or CS.

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Cite This Study

Menza et al. (Tue,) studied this question.

synapsesocial.com/papers/69c771198bbfbc51511e0e8e https://doi.org/https://doi.org/10.1093/cid/ciag209

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