Protective effects and mechanisms of Panax notoginseng saponins against gp120-induced cognitive impairment: a network pharmacology and metabolomics study | Synapse
March 28, 2026Journal of Pharmacy and Pharmacology0 citations
Protective effects and mechanisms of Panax notoginseng saponins against gp120-induced cognitive impairment: a network pharmacology and metabolomics study
This research examines the protective effects of Panax notoginseng saponins on cognitive impairment caused by gp120, focusing on underlying mechanisms.
Investigated neuroprotective effects of Panax notoginseng saponins
Utilized network pharmacology and metabolomics approaches
Analyzed modulation of the NOD-like receptor signaling pathway
Demonstrated neuroprotection against gp120-induced cognitive impairment
Showed suppression of neuroinflammation
Inhibited apoptosis in neural cells
Abstract
PNS confers neuroprotection against gp120-induced cognitive impairment by modulating the NOD-like receptor signaling pathway, which suppresses neuroinflammation and inhibits apoptosis.