Schizophrenia-associated complement C4 impairs synaptic connectivity and decreases microglia-synapse interactions through CR3 signaling

Key Points

• The research aims to explore how complement C4 overexpression affects synaptic connectivity and interactions between microglia and synapses.
• Examined the effects of C4 overexpression on synapse density in cortical regions.
• Analyzed the interactions between microglia and synapses under C4-OE conditions.
• Monitored changes in synaptic function linked to complement signaling.
• C4 overexpression significantly reduces cortical synapse density.
• Impairment of synaptic function correlates with decreased interaction between microglia and synapses.
• Observed changes implicate CR3 signaling in these effects.