Nickel-catalyzed hydroxymethylation with α-silicon N -methoxyphthalimides via radical Brook rearrangement

Key Points

• The research aims to explore nickel-catalyzed hydroxymethylation using α-silicon N-methoxyphthalimides through radical mechanisms.
• Conducted nickel-catalyzed reactions on aryl electrophiles.
• Utilized α-silicon N-methoxyphthalimides as reactants.
• Applied radical Brook rearrangement to facilitate the process.
• Successfully achieved the installation of hydroxymethyl groups.
• Demonstrated functional-group tolerance in diverse conditions.
• Highlighted the potential for late-stage modifications in synthesis.