Identifies specific cardiac troponin I sequence motifs that drive T cell-mediated myocardial inflammation, fibrosis, and contractile dysfunction in a murine model.
Transfer of troponin I-specific T cells can induce inflammation and fibrosis in wild-type mice, which leads to deterioration of contractile function. Furthermore, 2 sequence motifs of cTnI that induce inflammation and fibrosis in the myocardium are characterized.
Kaya et al. (Tue,) studied this question.