Identifies specific cardiac troponin I sequence motifs that drive T cell-mediated myocardial inflammation, fibrosis, and contractile dysfunction in a murine model.
May inform epitope-targeted immunomodulation in myocarditis; leaves open human translation from murine data.
Transfer of troponin I-specific T cells can induce inflammation and fibrosis in wild-type mice, which leads to deterioration of contractile function. Furthermore, 2 sequence motifs of cTnI that induce inflammation and fibrosis in the myocardium are characterized.
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Kaya et al. (2008) studied this question.
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