Key result
T-bet deficiency in mice leads to severe IL-17-mediated experimental autoimmune myocarditis, demonstrating that T-bet negatively regulates autoimmunity by suppressing local IL-17 production.
T-bet negatively regulates autoimmune myocarditis by suppressing local IL-17 production, highlighting a protective role of T-bet in inflammatory heart disease.
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Extends T-bet/IL-17 insights in murine myocarditis; leaves open translation to human inflammatory cardiomyopathy.
Rangachari et al. (2006) studied Experimental autoimmune myocarditis. T-bet deficiency / IL-17 depletion vs. T-bet+/+ control mice was evaluated on Development and severity of autoimmune heart disease (EAM). T-bet deficiency in mice leads to severe IL-17-mediated experimental autoimmune myocarditis, demonstrating that T-bet negatively regulates autoimmunity by suppressing local IL-17 production.
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