Key result
Neutralization of IL-17 by active vaccination reduced myocarditis and heart autoantibody responses in a mouse model of experimental autoimmune myocarditis.
Why the study?
Does neutralization of IL-23 or IL-17 reduce experimental autoimmune myocarditis in mice?
Population
Mice models of experimental autoimmune myocarditis (EAM), including IL-12p40-/- and IL-12p35-/- mice
Comparison
Neutralizing IL-23 antibody and active… vs Control/untreated mice (implied)
Design
Preclinical
Authors
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Supports IL-17 neutralization in myocarditis models; leaves open human translation and requires clinical trials.
Does neutralization of IL-23 or IL-17 reduce experimental autoimmune myocarditis in mice?
Targeting IL-23 and IL-17 through vaccination or neutralizing antibodies reduces experimental autoimmune myocarditis, highlighting a potential therapeutic pathway for preventing dilated cardiomyopathy.
Sonderegger et al. (2006) studied Experimental autoimmune myocarditis. Neutralization of IL-17 by active vaccination and neutralizing IL-23 antibody was evaluated on Myocarditis and heart autoantibody responses. Neutralization of IL-17 by active vaccination reduced myocarditis and heart autoantibody responses in a mouse model of experimental autoimmune myocarditis.
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