Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury

Key Points

• To characterize cell type-specific transcriptomic responses and molecular heterogeneity in human critical illness-associated acute kidney injury.
• Performed single-cell transcriptomic profiling to analyze cell type-specific gene expression patterns in human critical illness-associated acute kidney injury.
• Identified recurrent, disease-associated transcriptomic response patterns in kidney epithelial cells.
• Uncovered substantial inter-individual molecular heterogeneity across patients with critical illness-associated acute kidney injury.