Mechanoredox Radical Annulation for the Solvent-Free Synthesis of 2-Substituted Benzothiophenes

Key Points

• The aim is to synthesize 2-substituted benzothiophenes using mechanoredox radical annulation.
• Utilized ball-milling for the reaction process
• Employed 2-(methylthio)benzenediazonium salts and alkynes as reactants
• Achieved synthesis without need for solvent, photoredox, or electrochemical systems
• Successfully produced 2-substituted benzothiophenes through radical annulation
• Showed effective single-electron transfer driven by mechanical energy