Serum protein alterations characterize feline chronic gingivostomatitis: a case-control study of electrophoresis, immunoglobulin, and cytokine profiles

Key Points

• This study aims to explore systemic immune responses in feline chronic gingivostomatitis (FCGS) through serum protein analysis.
• Conducted a case-control analysis of serum samples from cats diagnosed with FCGS and healthy controls.
• Used electrophoresis to assess protein profiles and measured cytokines and immunoglobulins.
• Examined the correlation between oromucosal inflammation and serum protein changes.
• Identified hyperglobulinemia in cats with FCGS compared to healthy controls.
• Observed significant activation of cytokines IL-8, IL-4, IFN-γ, and IL-6 associated with inflammation.
• Findings suggest these cytokines could be targeted for new immunomodulatory treatments.