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April 10, 2026Open Access

Genomic codon usage reveals First-Classness: large-scale empirical validation across the tree of life

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Authors

DMDouglas Joseph Huntington Moore

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Overview

This biological repository validates genomic codon usage across species, indicating systematic consistency in codon families.

Key Points

  • The research aims to validate the structural consistency of genomic codon usage with the concept of First-Classness across diverse species.
  • Conducted analysis on codon usage across 70,950 RefSeq species.
  • Extended robustness analyses were performed on 1,447,521 GenBank entries.
  • Performed uniformity analysis within codon families and fine structure analyses for six-fold families.
  • Utilized computational routines to verify codon-family definitions.
  • Successfully reproduced the findings on codon usage and First-Classness across the analyzed species.
  • Demonstrated uniformity in codon usage within families, consistent with the proposed model.
  • Confirmed robustness of codon-family partition through verification scripts.

Cite This Study

Douglas Joseph Huntington Moore (2025) studied this question.

synapsesocial.com/papers/69d8948f6c1944d70ce056fehttps://doi.org/10.5281/zenodo.19450144
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genomic codon usage reveals First-Classness - Reviewer verification WSL package2026
  2. 2Sampling informational properties of codon usage through the tree of life2025
  3. 3Sampling informational properties of codon usage through the tree of life2025
  4. 4First-Classness yields a unique 64 → 20 genetic code: Supplementary Documentation Package2026
  5. 5First-Classness yields a unique 64 → 201 genetic code: beyond group-theoretic symmetries: (PDF version)2026