A Robust Pd(BIAN-IPr#)Cl2(H2O) Catalyst Employing Water as a Disposable Ligand for C–S Cross Coupling of Aryl Chlorides and Thiols

Key Points

• The study aims to develop a robust catalytic method for synthesizing aryl thioethers using water as a ligand.
• Utilized a Pd(BIAN-IPr#)Cl2(H2O) catalyst.
• Conducted cross-coupling reactions between aryl chlorides and thiols.
• Employed water as a disposable ligand in the reaction.
• Achieved high efficiency in the reaction conditions.
• Successfully produced versatile aryl thioethers.
• Demonstrated broad applicability across medicinal and agricultural chemistry.