Are there sex differences in doxorubicin-mediated cardiotoxicity?
There are significant sex differences in doxorubicin-mediated cardiotoxicity, potentially mediated by cardiac mitochondrial dysfunction and AMPK.
Altogether, these results clearly evidence sex differences in doxorubicin toxicity. Cardiac mitochondrial dysfunction and adenosine monophosphate-activated protein kinase seem as critical sites of sex differences in cardiotoxicity as evidenced by significant statistical interactions between sex and treatment effects.
Moulin et al. (Tue,) studied this question.