November 25, 2014Circulation Heart FailureOpen Access

Sexual Dimorphism of Doxorubicin-Mediated Cardiotoxicity

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Why the study?

Are there sex differences in doxorubicin-mediated cardiotoxicity?

Comparison

Doxorubicin vs Sex (male vs female)

Design

Preclinical

Authors

MMMaryline MoulinCentre National de la Recherche Scientifique JPJérôme PiquereauUniversité Paris-Sud PMPhilippe MatéoCentre National de la Recherche Scientifique

Discussion

Member takes

Implication

There are significant sex differences in doxorubicin-mediated cardiotoxicity, potentially mediated by cardiac mitochondrial dysfunction and AMPK.

Structured PICO

Are there sex differences in doxorubicin-mediated cardiotoxicity?

Intervention

Doxorubicin

Comparator

Sex (male vs female)

Outcome

Cardiotoxicity (cardiac mitochondrial dysfunction and adenosine monophosphate-activated protein kinase)surrogate

There are significant sex differences in doxorubicin-mediated cardiotoxicity, potentially mediated by cardiac mitochondrial dysfunction and AMPK.

Cite This Study

Moulin et al. (2014) studied this question.

synapsesocial.com/papers/69dada810d8d6ef495a3c619 https://doi.org/10.1161/circheartfailure.114.001180

Topics

Heart failure HFrEF treatment

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Implication

There are significant sex differences in doxorubicin-mediated cardiotoxicity, potentially mediated by cardiac mitochondrial dysfunction and AMPK.

Sexual Dimorphism of Doxorubicin-Mediated Cardiotoxicity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Sexual Dimorphism of Doxorubicin-Mediated Cardiotoxicity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider