March 26, 2013Toxicologic Pathology
Sex-related Differences in Mast Cell Activity and Doxorubicin Toxicity
Why the study?
Does doxorubicin cardiotoxicity differ by sex and ovariectomy status in spontaneously hypertensive rats?
Population
Adult male and female spontaneously hypertensive rats (SHR), including some ovariectomized (OVX) females
Comparison
Doxorubicin 1 mg/kg IV weekly for 9, 10, or 12… vs Saline IV weekly for 9, 10, or 12 weeks
Design
Preclinical
Follow-up
9, 10, or 12 weeks
Authors
Discussion
Loading...
Member takes
Overview
Does not support sex-based doxorubicin dosing changes; leaves open estrogen's role in human cardiotoxicity.
Structured PICO
Does doxorubicin cardiotoxicity differ by sex and ovariectomy status in spontaneously hypertensive rats?
P
Population
Adult male and female spontaneously hypertensive rats (SHR), including some ovariectomized (OVX) females
I
Intervention
Doxorubicin 1 mg/kg IV weekly for 9, 10, or 12 weeks
C
Comparator
Saline IV weekly for 9, 10, or 12 weeks
O
Outcome
Cardiomyopathy scores and serum levels of cTnTsurrogate
Adult male and ovariectomized female rats show greater susceptibility to doxorubicin-induced cardiotoxicity than normal females, potentially mediated by increased cardiac mast cell activity.
Cite This Study
Zhang et al. (2013) studied this question.