March 15, 2016Cardio-OncologyOpen Access

The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity

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Why the study?

Does genetic background influence the sexual dimorphism of doxorubicin-induced cardiotoxicity in rat models?

Population

Male and female Wistar Kyoto (WKY) and Spontaneous Hypertensive Heart Failure (SHHF) rats

Design

Preclinical

Follow-up

12 weeks after administration

Authors

BZBeshay N. ZordokyUniversity of Minnesota MRM. Judith RadinThe Ohio State University LHLois Jane HellerUniversity of Minnesota, Duluth

Discussion

Member takes

Implication

Sex-genetic interactions in rat DOX models are hypothesis-generating; leaves open whether background modulates human cardiotoxicity risk.

Structured PICO

Does genetic background influence the sexual dimorphism of doxorubicin-induced cardiotoxicity in rat models?

Population

Male and female Wistar Kyoto (WKY) and Spontaneous Hypertensive Heart Failure (SHHF) rats

Intervention

Doxorubicin (DOX) administered in eight doses of 2 mg/kg/week

Outcome

Cardiac function (assessed by trans-thoracic echocardiography), systolic blood pressure, and heart and kidney histopathologysurrogate

Genetic background significantly influences the sexual dimorphism of doxorubicin-induced cardiotoxicity, and doxorubicin-induced nephrotoxicity strongly correlates with cardiac dysfunction in rodent models.

Cite This Study

Zordoky et al. (2016) studied this question.

synapsesocial.com/papers/6a756d47e42ca79ec1e71751 https://doi.org/10.1186/s40959-016-0013-3

View Full Paper

Ask AI

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The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider