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January 7, 2017Biology of Sex DifferencesOpen Access

Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice

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Why the study?

Does acute doxorubicin exposure alter cardiac cytochrome P450 gene expression in a sex-dependent manner in adult C57Bl/6 mice?

Population

Male and female adult C57Bl/6 mice

Comparison

Single intraperitoneal injection of 20 mg/kg… vs Saline injection

Design

Preclinical

Follow-up

1 day or 6 days

Authors

MGMarianne GrantUniversity of MinnesotaDSDavis SeeligUniversity of MinnesotaLSLeslie C. SharkeyTufts University

Discussion

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Overview

DOX induces sex-dependent cardiac CYP expression in mice; hypothesis-generating for mechanisms of female cardiotoxicity protection.

Structured PICO

Does acute doxorubicin exposure alter cardiac cytochrome P450 gene expression in a sex-dependent manner in adult C57Bl/6 mice?

P
Population
Male and female adult C57Bl/6 mice
I
Intervention
Single intraperitoneal injection of 20 mg/kg doxorubicin (DOX)
C
Comparator
Saline injection
O
Outcome
Expression of cytochrome P450 (CYP) genes, natriuretic peptides, inflammatory and apoptotic markers, and cardiac function assessed by trans-thoracic echocardiographysurrogate

Doxorubicin induces sex-specific alterations in cardiac cytochrome P450 gene expression, potentially explaining why female mice are protected against acute doxorubicin-induced cardiotoxicity.

Cite This Study

Grant et al. (2017) studied this question.

synapsesocial.com/papers/6a6ff6206c240de38cdba2a0https://doi.org/10.1186/s13293-016-0124-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The interplay between genetic background and sexual dimorphism of doxorubicin-induced cardiotoxicity2016 · 23 citations
  2. 2Sex Differences in Doxorubicin‐Induced Cardiotoxicity: Insights from Transcriptome Analysis2024 · 6 citations
  3. 3Sexual Dimorphism in Doxorubicin-induced Systemic Inflammation: Implications for Hepatic Cytochrome P450 Regulation2020 · 25 citations
  4. 4Age‐ and sex‐specific modulation of human cardiac electrophysiology by doxorubicin2026 · 4 citations
  5. 5Potential role of tryptophan metabolites in the sex-based differences in doxorubicin-induced chronic cardiotoxicity in a rat model2026