What question did this study set out to answer?

To differentiate between sarcoid reaction, sarcoidosis, and pancreatic adenocarcinoma recurrence.

April 12, 2026Surgical Case Reports0 citationsOpen Access

Coexisting Sarcoid Reaction and Sarcoidosis Requiring Differentiation from Pancreatic Adenocarcinoma Recurrence: A Case Report

RHRyo HorieTokyo Metropolitan Tama Medical Center MTMakoto Takahashi THTatsuya HayashiTokyo Metropolitan Tama Medical Center

Key Points

To differentiate between sarcoid reaction, sarcoidosis, and pancreatic adenocarcinoma recurrence.
Case report of a patient with sarcoid reaction and sarcoidosis
Histological examination of lymph nodes
Comparison of findings with pancreatic adenocarcinoma characteristics
Identification of sarcoid reaction alongside sarcoidosis
Difficulties in distinguishing from PDAC recurrence
Emphasis on careful histopathological evaluation for accurate diagnosis

Abstract

INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is one of the most severe malignant tumors. The recurrence rate is high, even after radical surgery. A sarcoid reaction is a histological finding that occurs in the lymph nodes in response to malignant tumors, infections, or foreign substances. Its histopathology is similar to that of sarcoidosis. Here, we report a case of coexisting sarcoid reaction and sarcoidosis that required differentiation from PDAC recurrence.

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