Plasma neurofilament light chain and glial fibrillary acidic protein in the differential diagnosis of acute vertigo in the emergency department

Key Points

• The aim is to evaluate the diagnostic role of plasma neurofilament light chain and glial fibrillary acidic protein in distinguishing the causes of acute vertigo.
• Measured pNfL and pGFAP levels in patients presenting with acute vertigo.
• Compared biomarker levels between patients with potential central causes vs. non-central causes.
• Analyzed negative predictive value of pNfL.
• Found significantly higher levels of pNfL and pGFAP in patients with potential central causes of vertigo (PCS).
• Demonstrated that pNfL has a high negative predictive value for ruling out PCS in acute vertigo cases.