Long-term high-fat diet induces an imbalance in pro- and anti-oxidant mechanisms in perivascular adipose tissue, which aggravates endothelial dysfunction.
We suggest that the imbalance between pro-oxidant (NOX, superoxide anions, hydrogen peroxide) and anti-oxidant (eNOS, NO, ecSOD, GSSG) mechanisms in PVAT after long-term HFD might contribute to the aggravation of endothelial dysfunction.
Gil‐Ortega et al. (Wed,) studied this question.