High Expression of PAPP ‐A Predicts Poor Outcomes in Oestrogen Receptor‐Positive Breast Cancer Patients

Key Points

• This research aims to investigate the relationship between PAPP-A expression and prognosis in estrogen receptor-positive breast cancer.
• Analyzed PAPP-A expression levels in breast cancer tissues
• Correlated PAPP-A levels with clinical outcomes
• Assessed activation of the IGF-1/IGF-1R pathway
• Higher PAPP-A expression is linked to worse outcomes in ER-positive breast cancer
• PAPP-A correlates with increased activation of the IGF-1/IGF-1R pathway