Electromagnetic Milling-Promoted Steel Rods-enabled Sonogashira Coupling Reactions of Aryl halides and Terminal alkynes

Key Points

• To investigate the effectiveness of nickel-catalyzed Sonogashira reactions without traditional co-catalysts and heating.
• Conducted Sonogashira reactions using nickel as the main catalyst.
• Utilized electromagnetic milling to promote reactions.
• Examined the coupling between aryl halides and terminal alkynes.
• Successfully achieved C(sp²)–C(sp) bond formation without copper co-catalysts.
• Reduced need for solvents and inert atmospheres in the reaction process.