Electromagnetic Milling-Promoted Steel Rods-enabled Sonogashira Coupling Reactions of Aryl halides and Terminal alkynes

Xinyao Liu; Yanyan Chen; Qiuhong Ma; Meng Yu; Wenjie Guo; Bao-Ju Wang; Qiang Liu; Rujun Yu; Qing Liu; Hui Liu

doi:10.1039/d6mr00022c

January 1, 2026RSC MechanochemistryOpen Access

Electromagnetic Milling-Promoted Steel Rods-enabled Sonogashira Coupling Reactions of Aryl halides and Terminal alkynes

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Key Points

To investigate the effectiveness of nickel-catalyzed Sonogashira reactions without traditional co-catalysts and heating.
Conducted Sonogashira reactions using nickel as the main catalyst.
Utilized electromagnetic milling to promote reactions.
Examined the coupling between aryl halides and terminal alkynes.
Successfully achieved C(sp²)–C(sp) bond formation without copper co-catalysts.
Reduced need for solvents and inert atmospheres in the reaction process.

Implication

Electromagnetic milling enhances Sonogashira reactions between aryl halides and alkynes, indicating efficiency improvements.

Abstract

Nickel-catalyzed Sonogashira reactions between aryl halides and terminal alkynes have become a powerful method for constructing C(sp²)–C(sp) bonds. Conventional approaches typically required copper co-catalysts, solvents, inert atmospheres, and external heating....

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69df2b65e4eeef8a2a6b05f0 https://doi.org/10.1039/d6mr00022c

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Electromagnetic Milling-Promoted Steel Rods-enabled Sonogashira Coupling Reactions of Aryl halides and Terminal alkynes

Key Points

Implication

Abstract

Discussion

Cite This Study

Electromagnetic Milling-Promoted Steel Rods-enabled Sonogashira Coupling Reactions of Aryl halides and Terminal alkynes

Key Points

Implication

Abstract

Discussion

Cite This Study

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