Frequency‐Dependent Effects of Transauricular Vagus Nerve Stimulation on Alleviating Visceral Hypersensitivity: Involvement of the Nesfatin‐1/ CRF / CRF1R Pathway

Key Points

• This research aims to explore how transauricular vagus nerve stimulation affects visceral hypersensitivity through specific signaling pathways.
• Utilized transauricular vagus nerve stimulation on rats
• Assessed visceral pain through behavioral responses
• Investigated the nesfatin-1/CRF/CRF1R signaling pathway's involvement
• Compared effects of different stimulation frequencies
• Transauricular vagus nerve stimulation significantly reduced visceral pain
• 2 Hz stimulation had a stronger analgesic effect than other frequencies
• Nesfatin-1/CRF/CRF1R pathway was implicated in the pain relief mechanism