The research investigates the mechanisms by which Majoon Ushba alleviates psoriatic inflammation and keratinocyte ferroptosis.
Examined the impact of Majoon Ushba on IL-17A sensitized keratinocytes
Analyzed the role of JAK-2-STAT-3 signaling
Measured inflammatory responses in an imiquimod-induced model of psoriasis
Majoon Ushba reduced IL-17A induced inflammation in keratinocytes
The treatment mitigated signs of ferroptosis
Inhibition of the JAK-2-STAT-3 pathway was observed as a mechanism of action
Abstract
In conclusion, our preliminary findings reveal a plausible mechanistic basis for the anti-psoriatic efficacy of Majoon Ushba, warranting larger clinical trials in psoriasis patient cohorts.