Fibrin-targeted and pH-responsive liposomes for synergistic thrombolysis and thrombotic microenvironment reprogramming

Key Points

• The aim is to enhance thrombolytic therapy by developing targeted liposomes that respond to pH changes.
• Developed tLipo@UA liposomes targeting fibrin.
• Tested the response of liposomes to varying pH levels.
• Evaluated thrombolytic efficacy in thrombotic microenvironments.
• tLipo@UA showed increased effectiveness in thrombus breakdown.
• Demonstrated reduced bleeding risks compared to traditional therapies.
• Exhibited significant reprogramming of the thrombotic microenvironment.