Cross-Tissue Transcriptome-Wide Association Study and TWAS-FOCUS Fine-Mapping Reveal Novel Susceptibility Genes for Primary Open-Angle Glaucoma

Key Points

• Identifying novel susceptibility genes related to primary open-angle glaucoma (POAG) for improving diagnosis and treatment.
• Conducted a transcriptome-wide association study across different tissues
• Utilized TWAS-FOCUS for fine-mapping genetic variants
• Validated candidate genes through clinical data
• Identified AFAP1 and FMNL2 as new susceptibility genes for POAG
• Findings suggest these genes could enhance early diagnosis
• Potential therapeutic targets for glaucoma management are proposed