Novel pyrimidine-triazole conjugates for targeted inhibition of EGFR: synthesis and biological evaluation

Key Points

• The aim is to develop new compounds that effectively inhibit the EGFR pathway.
• Synthesis of pyrimidine-triazole conjugates
• Biological evaluation of the compounds' efficacy
• Identification of lead compounds for further development
• SM-1F identified as a promising lead compound
• Exhibits significant potential for EGFR inhibition
• Supports further research into its development