Effects and Mechanism of Medicated Bath Formula on Wound Healing in Rat Models of Pressure Ulcers

Key Points

• The aim is to investigate the impact of a medicated bath formula on wound healing in pressure ulcer models using rats.
• 108 healthy SD rats were divided into several groups: normal, model, and different doses of medicated bath formula.
• A pressure ulcer model was created using magnets in all groups except the normal group.
• Histological changes were observed using HE staining, and serum levels of CRP, TNF-alpha, and IL-6 were measured.
• PCR was used to assess the expression of IL-6 and EGFR in wound tissue.
• The medium-dose medicated bath group showed the shortest healing time (complete healing by day 21) and highest healing rate (P<0.05).
• CRP, TNF-alpha, and IL-6 levels significantly decreased across all medicated bath and control groups compared to the model group (P<0.05).
• IL-6 expression decreased while EGFR expression significantly increased in all medicated bath groups (P<0.05).