Mechanistic study of italicJiajian Bazhen Decoction/italic （加减八珍汤） in ameliorating chronic cerebral ischemia injury through ferroptosis pathway

Key Points

• This research investigates how Jiajian Bazhen Decoction affects ferroptosis to treat chronic cerebral ischemia injury.
• Four groups of rats were randomly assigned: sham operation, model, Jiajian Bazhen Decoction, and Nimo Toxin group.
• After a 28-day intervention, specimens were collected for detection.
• Learning and memory abilities were assessed using the Morris water maze; biochemical evaluations of Fe²⁺, ROS, and MDA were conducted.
• The model group rats showed significantly prolonged escape latency and reduced time in the target quadrant compared to the sham group (P<0.01).
• Increased levels of Fe²⁺, ROS, and MDA were present in the ischemic brain tissue (P<0.01).
• Compared to the model group, both treatment groups showed reduced escape latency and increased time in the target quadrant (P<0.01).