LS confers risk for pediatric colorectal adenoma and cancer. CRC in this population manifests predominantly as left-sided, advanced-stage CRC, driven by loss-of-function variants in MLH1 and MSH2. These findings contrast with the right-sided predominant adult LS and suggest age-specific biology. Increased awareness and further research are needed to inform age-appropriate surveillance strategies.
Phen et al. (Mon,) studied this question.