Safety and Efficacy of Tranexamic Acid in Urologic Surgery: Results from the International, Randomized, Placebo-Controlled POISE-3 Trial

Key Points

• To evaluate the safety and efficacy of tranexamic acid in preventing major bleeding during urologic surgery.
• Conducted an international, randomized, placebo-controlled trial (POISE-3)
• Assessed major bleeding in patients undergoing urologic surgery
• Compared outcomes between tranexamic acid and placebo groups
• Tranexamic acid reduced the occurrence of major bleeding compared to placebo.
• The intervention was especially beneficial in surgeries with a high bleeding risk.