Total Synthesis of (+)-Xiamycin G via Acetanilide Assisted Two-Fold Csp2-H Functionalization

Key Points

• This research aims to achieve the first total synthesis of xiamycin G, a unique indolosesquiterpene alkaloid.
• Utilized aniline-directed Csp2-H functionalization techniques.
• Executed two-fold functionalization strategy for synthesis.
• Applied asymmetric synthesis methods to enhance yield.
• Successfully synthesized (+)-xiamycin G with high stereochemical purity.
• Achieved notable efficiency in the functionalization process.
• Demonstrated the viability of using acetanilide in the synthesis approach.