Total Synthesis of (+)-Xiamycin G via Acetanilide Assisted Two-Fold Csp2-H Functionalization

Rhituparna Nandi; Souvik Biswas; S. Sadhukhan; Apurba Das; Alakesh Bisai

doi:10.1039/d6cc00441e

January 1, 2026Chemical Communications

Total Synthesis of (+)-Xiamycin G via Acetanilide Assisted Two-Fold Csp2-H Functionalization

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Key Points

This research aims to achieve the first total synthesis of xiamycin G, a unique indolosesquiterpene alkaloid.
Utilized aniline-directed Csp2-H functionalization techniques.
Executed two-fold functionalization strategy for synthesis.
Applied asymmetric synthesis methods to enhance yield.
Successfully synthesized (+)-xiamycin G with high stereochemical purity.
Achieved notable efficiency in the functionalization process.
Demonstrated the viability of using acetanilide in the synthesis approach.

Implication

Demonstrates the first synthesis of xiamycin G, indicating effective methods for complex alkaloid production.

Abstract

The first asymmetric total synthesis of the structurally unique naturally occurring indolosesquiterpene alkaloid, xiamycin G (1b) has been accomplished via a two-fold Csp2-H functionalizations. The aniline directed Csp2-H functionalization to...

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Cite This Study

Nandi et al. (2026) studied this question.

synapsesocial.com/papers/69ec5a2588ba6daa22dabbe1 https://doi.org/10.1039/d6cc00441e

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Total Synthesis of (+)-Xiamycin G via Acetanilide Assisted Two-Fold Csp2-H Functionalization

Key Points

Implication

Abstract

Discussion

Cite This Study

Total Synthesis of (+)-Xiamycin G via Acetanilide Assisted Two-Fold Csp2-H Functionalization

Key Points

Implication

Abstract

Discussion

Cite This Study

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