Poor sleep patterns are robustly associated with an increased risk and severity of CKM syndrome. While systemic inflammation was correlated with both sleep disturbances and CKM, its role as an independent mediator was largely explained by shared variance with obesity and metabolic factors. These findings underscore sleep health as a potential target for multimodal risk reduction within the CKM framework, though causality needs confirmation in longitudinal studies.
Hu et al. (Thu,) studied this question.