Copper-catalyzed one-pot synthesis of isoquinolines via oxidative α-amination under mild and sustainable conditions

Key Points

• This research aims to develop a copper-catalyzed method for the efficient synthesis of isoquinolines.
• Utilized a multicomponent one-pot synthesis approach
• Applied a modified Pomeranz–Fritsch-type cyclization
• Conducted the synthesis under mild and sustainable conditions
• Successfully synthesized isoquinolines in a single step
• Achieved high yield and efficiency
• Showed compatibility with various functional groups