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April 29, 2026Chemistry & Biodiversity0 citations

Unlocking the Antidiabetic and Antioxidant Potentials of Phyllanthus amarus Using In Vitro and In Silico Approaches

SISuccess IkoyaDelta State University JAJoy Onyewonuwa AchaDelta Air Lines (United States)LELisa Ilobekemen EkakitieDelta Air Lines (United States)

Key Points

This research aims to explore the antidiabetic and antioxidant potentials of Phyllanthus amarus using both in vitro and in silico methods.
In vitro analysis to evaluate antidiabetic and antioxidant properties
In silico computational analysis to identify bioactive compounds
Assessment of binding affinities to α-amylase and Keap1
DL-α-tocopherol and γ-sitosterol show strong binding affinities to α-amylase and Keap1, respectively
Bioactive compounds surpass effectiveness of standard inhibitors
MePa evaluated as a promising natural source for drug development.

Abstract

= 5.8 ± 0.8 µg/mL). Computational analysis identified DL-α-tocopherol and γ-sitosterol as key bioactive compounds with strong binding affinities to α-amylase and Keap1, respectively, surpassing standard inhibitors. These findings highlight MEPa as a promising natural source for antidiabetic and antioxidant drug development.

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